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Friday, 2-Sep-2011 00:58 Email | Share | Bookmark
Flash Freezing of Eggs and Embryos

Laboratories for assisted reproductive technological innovation (Artwork) have productively frozen sperm, embryos, and even eggs for some time now. Nevertheless, achievement in this context is a relative expression from a historical point of view. The freezing of sperm, for example, worked very properly for several many years with very couple of technological adjustments to the basic freezing protocols-this is since sperm do not have that considerably h2o in their composition-the much more water there is the larger the likelihood that freezing damage will take place.Embryos have a a lot larger h2o composition, and have been far more challenging to freeze and thaw efficiently. Still, over the past twenty five years, live birth charges from thawed embryos have enhanced from around five% to the level where, in the very best plans, there is quite small distinction from outcomes obtained with the transfer of non-frozen embryos in all patient groups.Eggs have been especially tough simply because they have special structures that are really susceptible to freezing damage. With that stated, thawed eggs also have started to contribute substantially to dwell births from Artwork the globe over. These improves in reside birth premiums for thawed embryos and eggs have took place via incremental refinements of what is termed "managed price" freezing, a approach of gradually lowering the temperature of the freezing remedies that the eggs or embryos are immersed in above a a number of-hour period. The now-frozen specimens are then plunged into storage tanks of liquid nitrogen in which they will stay-sometimes for several many years-until finally they are needed.Recently, a substantial technological breakthrough makes it possible for very speedy freezing of eggs and embryos. This new technique, called "flash freezing" (or vitrification) seems to reduced the incidence of freezing damage, and as a result has the potential for increased pregnancy and reside birth rates as compared to the controlled fee approach. The science powering secure, non-injurious freezing strategies of all kinds is avoidance of the advancement of ice crystals forming inside of the specimens, be they sperm, eggs or embryos. The flash freezing approach appears to minimize ice crystal formation, and is consequently an inherently safer method. \nIn fact, survival on thawing of flash frozen eggs is so higher (better than 95% generally) that it is now possible to financial institution eggs removed and frozen from anonymous donors, and potential recipients may decide on from a catalog that contains information about the donor equivalent to what 1 finds with sperm banking institutions. From the standpoint of patient basic safety and ease, this represents a sizeable adjust from the prior-a paradigm shift, really-that brings the practice of anonymous egg donation into conformity with tissue banking legal guidelines that are applied to every single other kind of tissue banking.Right after months of evaluative scientific tests of the finest flash freezing techniques at the moment obtainable, the Art Reproductive Center is properly into the procedure of transition from managed price to flash freezing of eggs by way of blastocyst levels. Many pregnancies have been set up at this stage from thawed, flash frozen blastocysts, and eggs and cleavage stage embryos are now staying frozen in this way as well.\nRelated Sites : infertility treatment


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